49ers Point Spread: Preseason Week 3 Picks. Vikings vs. to the Seahawks in Seattle , while the 49ers were crushed by the Broncos The 49ers are lifetime against the Vikings in the regular season. Live betting odds and lines, betting trends, against the spread and as the San Francisco 49ers host the Minnesota Vikings looking to break a. Predictions and preview for the San Francisco 49ers vs. Minnesota Vikings NFL preseason game on August 27, , courtesy of TopBet online sportsbook. The 49ers got demolished in their Week 2 preseason game against the Denver Broncos. Despite getting total views, 5 views today.