Arizona Cardinals vs. Dallas Cowboys - 9/25/17 NFL Pick, Odds, and Prediction New York Giants () at Philadelphia Eagles () NFL Football: Sunday, September 24, at pm (Lincoln Financial Field) The Line: Philadelphia Sun, Sep 24. After an exhilarating comeback win in Week 1 over the Arizona Cardinals, the Detroit Lions face a test on the road Monday night against the. New York Giants Vs. Detroit Lions: Updated Odds And Picks After Odell Week 2 of the NFL season will conclude with tonight's Monday Night against the Arizona Cardinals, while the G-Men looked confused on that. Week 2 ends Monday night at MetLife Stadium with the New York Giants hosting the Detroit Lions. The line is Giants -3, meaning Vegas. lions vs. cardinals (Photo: Raj Mehta, USA TODAY Sports) It's one week, but the Giants are tied for last in the NFL in rushing after amassing. NFL Network's Marc Sessler, Dan Hanzus, and Gregg Rosenthal pick who will win the Week 2 matchup.