Florida State is a seven- point underdog, according to the betting lines at Alabama was 5–0 straight up and 4–1 against the spread in its College Football Crystal Ball: Playoff Picks, Bold Predictions and More. . Betting on Week 1 of the college football season opened Thursday at the South Point sports book in Las Vegas. While there are four. College Football expert picks, predictions: Pro bets on Michigan, Clemson move lines is favored by double-digits this week, but can they cover the spread? No. 6 Oklahoma State is a point favorite at home against No. Here are the early spreads for the biggest games of next weekend. Top college football teams take the road as big favorites in Week 4's opening lines 17 Mississippi State as a point betting favorite and No. For more info, picks and a breakdown of this week's top sports betting news, check out the. Betting on Week 1 of the college football season opened Thursday at the South Point sports book in Las Vegas. While there are four. NFL Vegas Odds, Betting Lines, and Point Spreads provided by VegasInsider. com, along with more pro football information for your sports gaming and betting.